GenomeExplorer install readme, 09-Feb-03 To run GenomeExplorer on your PC: 1) install the Java Runtime Environment version 1.4.1. Check the version from a command prompt c:\> java -version 2) download genExp.jar, genExp.inf and gexExpDoc.zip from http://jic-bioinfo.bbsrc.ac.uk/bioinformatics-research/software/index.html. To help with configuration, you can download defaultDirStructure.zip (a zip file of empty directories). 3) download biojava.jar, jakarta-regex.jar and xcerces.jar from the biojava website 4) put all of the above files into the same directory and then unzip genExpDoc.zip. 5) install the bioinformatics programs you want to be able to run: a) clustalw b) ncbi-blast c) phylip 3.6a d) treeview e) chromtree Links to these downloads sites are provided on GenomeExplorer download page. 6) double click the genExp.jar file, or choose to open using javaw.exe. To run from the command line, cd to the directory containing genExp.jar and then type 'java -jar genExp.jar' c:\> cd genomeExplorerDir c:\genomeExplorerDir> java -jar genExp.jar Sometime clustalw will crash for no reason. If this is a problem for you, make a batch file (call it genExp.bat) with the following lines (the first one is designed to fail, so don't worry if the tmp.i doesn't exist): c:\bioProgramsDir\clustalw.exe -infile tmp.i java -jar c:\genomeExplorerDir\genExp.jar NB - you will need to ensure the paths are set correctly for your system. 7) choose 'settings' -> 'directories and executables...' to enter the paths to your installed bioinformatics programs, and default input and output directories. These settings are stored in the genExp.inf file. This file can be edited in a text editor if desired. If you downloaded defaultDirStructure.zip, it will be easier to do a 'search-and-replace' in a text editor. The documentation in unzipped from the genExpDoc.zip file will be available from within genomeExplorer if you set the 'genome explorer documentation directory' path to point to its directory. (This documentation needs to be updated for some programs, but should be still help in its current state.) GenomeExplorer should now run smoothly. If it doesn't, email me with you problems and I'll try to help you out. jenn.conn@bbsrc.ac.uk. p.s. GenomeExplorer is still under development. A more polished versions should be available shortly.